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Innovative Dental-Engineering Alliance Research Core
Innovative Dental-Engineering Alliance Research Core
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Prof. Hiroshi EGUSA(Visiting) |
Room: Tohoku University Graduate School of Dentistry, Building C, 7th Floor |
TEL: 022-717-8363 |
E-mail: egu(at)tohoku.ac.jp
Please replace “(at)” with “@”. |
HomePage: http://crbr.dent.tohoku.ac.jp/ |
- Research Field Regenerative medicine, Biomaterials, Prosthodontics
- Objective Innovation of medical technologies based on regenerative medicine and material science
- Current Topics
・Development of stem cell-based tissue engineering technologies
・Development of biomimetic materials for bone regeneration/dental implant
・Basic/clinical research on CAD/CAM-generated dental restorations
・Basic/clinical research on dental metal allergy
・Development of AI evaluation system for tooth preparation

Stiffness-tunable hydrogel-sandwich culture augments cardiomyocyte
differentiation of iPS cells
- Research Field Real world data analyses, social medicine
- Objective Analyzing the oral & general health conditions.
- Current Topics
• Association between oral health and social-economic and behavioral factors.
• Understanding the underlying mechanisms that lead to associations between broader social determinants and health (oral & general).
• The oral health care system and health inequalities.
• Infectious disease countermeasures and risk management.

the number of teeth has large impact for death
- Research Field Biomedical engineering, Biomaterials, Orthodontics
- Objective New medical device development by interdisciplinary integration research
- Current Topics
・Promotion of interdisciplinary researches regarding Interface Oral Health Science
・Research and development for new medical devices by industry-academic collaboration
・Development and clinical application of nickel-free shape memory alloys
・Research on high functionalization by surface modification of biomaterials
・Research on development of functional foods and evaluation of mastication

Development of innovative biomaterial aiming at both osseointegration and antibacterial
properties
- Research Field Biomaterials・Bioceramics・Bone regeneration
- Objective Design and functionalization of bioceramics for biomaterials
- Current Topics
・Development of bioactive materials
・Development of calcium phosphate materials
・Study of structure and solubility control
・Development and application of inorganic/organic composite materials as biomaterials
・Translational research of medical and dental biomaterials

- Research Field Microbiome Metabolic Function Analysis, Cellular Metabolic Function Analysis
- Objective Aiming to elucidate the causal relationship between the oral microbiome and host disease/health, based on the metabolic functions of both
- Current Topics
・Genomics, proteomics and metabolomics of oral microbial ecosystem (oral microbiome)
・Metabolism of oral microorganisms using an anaerobic experimental system and the association with systemic / oral health and diseases
・Caries / Periodontitis preventive properties of fluorides, sugar alcohols and tea catechins
・Evaluation of cariogenic potential of food products and sweeteners using pH-telemetry
・Oral microbiome-induced deterioration of dental biomaterials
・Metabolism of host cells, including oral cancer cells
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World-class “anaerobic experimental system”
essential for microbiome metabolism research |
Caries risk assessment device
using ISFET pH electrode |
- Research Field Prosthodontics, Dental Implantology, Biomaterials
- Objective Elucidating the background contributing to the advancement of prosthetic dental treatment, and developing new treatment techniques and medical devices
- Current Topics
・Biomechanics and mechanobiology for stomatognathic morphology and function based on in vivo measurements and evaluation.
・Studies on development and clinical application of novel biomaterials for prosthodontics, implantology and maxillofacial rehabilitation.
・Developmental and translational research for novel dental treatment technology and dental equipment based on multi-disciplinary research and academia-industrial collaboration.
・Studies on clinical outcome of prosthodontics, implantology and maxillofacial rehabilitation.
